Cidnavir | Cidofovir | Vistide | Details, Costing & Pricing

Cidnavir Injection is an antiviral drug that contains the active ingredient cidofovir. It is used to cure CMV retinitis, an eye infection in AIDS patients. CMV retinitis is an infection of the eye caused by the cytomegalovirus (CMV). The virus harm the retina of the eye, causing vision loss and eventually blindness. Patients suffering from AIDS are at a high risk of contracting this infection. Inform your doctor if you've had kidney disease or are currently on hemodialysis. The most serious side effect of this medication's treatment is kidney damage. If you have diabetes, consult your doctor before taking this medication.

Children should not be given Cidnavir Injection. Before taking this medication, your doctor may recommend you to stay hydrated. Breastfeeding is not recommended because the virus can transfer through the milk. Sodium is present in this antiviral medication. If you are on a salt-restricted diet, seek medical advice.

Uses of CIDNAVIR Injection

• In treatment of AIDS patients' ocular infections

Side effect of CIDNAVIR Injection

Unwanted symptoms induced by medications are known as side effects. Even though all medications have side effects, not everybody experiences them.

Common side effect

• Nausea
• Vomiting
• Headache
• Hair loss
• Weakness
• Fever
• Chills
• Difficulty in breathing
• Diarrhea
• Inflammation of the eye
• Reduced pressure in the eye

Serious side effect

• Kidney damage

Interactions with other medications

• Concomitant Cidofovir medication with products containing tenofovir disoproxil fumarate might enhance the pharmacodynamic interaction and risk of Fanconi syndrome.
• Probenecid increases the AUC of zidovudine. Patients receiving both medications should be closely monitored for zidovudine-induced haematological damage.

Consult your physician about any medications you are now taking or have recently taken.

Warnings and Precautions

• Cidofovir injection should be avoided in patients taking nephrotoxic medications. Such drugs must be stopped at least 7 days before starting cidofovir treatment.
• Close/exact monitoring of kidney function following cidofovir treatment is essential.
• Patients receiving therapy with cidofovir 75 mg/ml vials should have their neutrophil count checked.
• During cidofovir medication, patients' intraocular pressure should be checked.
• While on cidofovir medication, patients should be examined for signs and symptoms of uveitis or iritis.
• Nursing moms should not get the cidofovir 75 mg/ml injectable.
• Cidofovir is embryotoxic and should not be taken during pregnancy, according to women of reproductive potential.
• Patients who are hypersensitive to cidofovir should avoid using cidnavir.

Safety advice

Pregnancy

Cidnavir Injection can damage an unborn infant. Your doctor will prescribe it if it is plainly necessary. Before using this medication, inform your doctor if you are pregnant or intend to become pregnant.

Breastfeeding

Breastfeeding is not recommended since the virus might transmit through the milk.

Kidney

Inform your doctor if you have any renal problems.

Driving

You may feel fatigued and drowsy as a result of the medication. If you feel ill throughout the therapy, don't drive.

Storage

Handling CIDNAVIR injections should be done with caution. Injections of CIDNAVIR shouldn't be unsealed or damaged. It should be kept at a regulated room temperature of 20°C to 25°C (68°F to 77°F).

Frequently Asked Questions (FAQs)

How Cidnavir Injection works ?

Cidnavir Injection suppresses viral replication by specifically inhibiting the enzyme DNA polymerase.

How to use Cidnavir Injection ?

A health care provider will administer it to you intravenously. Before receiving Cidnavir Injection, you must consume food. Before taking this medication, your doctor may encourage you to drink lots of water.

Which drug class does cidofovir belong to?

Cidofovir particularly belongs to the antiviral medication class.

What other components are in the drug besides cidofovir?

Cidofovir is the active component in the medication, and the inactive substances include sodium hydroxide and hydrochloric acid.

What are the most often reported cidovir adverse effects?

Nausea, hair loss, vomiting, neutropenia, weakness, chills, low intraocular pressure, headache, uveitis, iritis, and other symptoms may occur.

How is cidofovir administered?

A healthcare practitioner should provide the required amount of cidofovir injection intravenously (into a vein).

What should you do if you take too much cidofovir?

In the event of a Cidofovir overdose, seek medical attention immediately and monitor the patient for signs and symptoms.

For more information, visit-

Cidnavir Injection: Know the Benefits, Uses, Side Effects and Availability and More

References

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Antiviral agents (nonretroviral), 12th edition, 2011, 1600-1601.
2. KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 798-802.
3. Tillomed Laboratories Limited, Electronic medicines compendium (emc), [ Revised on September 2017] [ Accessed on 4th May 2021].