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Bortether | Bortezomib | Velcade | Details, Costing & Pricing

Bortezomib is the active ingredient in the Bortether 2mg injection. It is a chemotherapeutic drug that is used to treat multiple myeloma and mantle cell lymphoma. Multiple myeloma is a malignant development of plasma cells, which are prevalent in bone marrow. Mantle cell lymphoma is a rare malignancy that affects the lymph nodes.

For patients who have not started treatment and are ineligible for blood stem cell transplant, this drug is used in conjunction with other chemotherapy medications such as pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone, or thalidomide.

Uses of Bortether 2 Injection

  • Multiple myeloma.
  • Mantle-cell lymphoma.

Benefits of Bortether 2 Injection

In Multiple myeloma

When you have multiple myeloma, your body destroys bone quicker than it replaces it. This causes bones to become brittle and painful. Bortether 2 Injection may be used in conjunction with other cancer therapies including chemotherapy. It is an important aspect of your therapy and helps patients with multiple myeloma live longer lives. This medication will eliminate the malignant cells and prevent them from growing and spreading to other places of the body. To obtain the best benefit, please follow your doctor's directions. Calcium and Vitamin D3 supplements are also useful and may be administered if you don't have high blood calcium levels.

In Mantle-cell lymphoma

Mantle-cell lymphoma, commonly known as non-lymphoma, Hodgkin's is a malignancy of the white blood cells in our bodies. White blood cells are the cells that aid in the fight against infections. Bortether 2 Injection inhibits cancer development by blocking the action of other chemicals essential for cancer growth and spread. To avoid illness, avoid crowds and wash your hands frequently. Drink plenty of fluids unless your doctor tells you not to.

Side effects of Bortether 2 Injection

Although all medications have side effects, not everyone experiences them. Visit your doctor if they worsen or if you are concerned.

Common side effects

  • Low blood platelets
  • Fatigue
  • Peripheral neuropathy
  • Psychiatric disturbances
  • Nausea
  • Vomiting
  • Loss of appetite
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Decreased appetite
  • Neutrophils (decreased white blood cell count)
  • Constipation

Serious side effects

  • Changes in heartbeat
  • High BP
  • Fainting and tiredness
  • Cough and chest tightness
  • Muscle cramps
  • Confusion, visual disturbances, seizures and headache
  • Breathlessness
  • Swelling of feet

How Bortether 2 Injection works?

Bortether 2 Injection acts by preventing or decreasing protein degradation in cells. As a result, a number of proteins in cancer cells rise, leading to their demise.

How to use Bortether 2 Injection?

This injection should be given by a skilled healthcare provider who is familiar with the administration of cytotoxic drugs.

Interactions with other medications

Consult your physician about any drugs you are now taking or have recently taken.

More information

Refrigerate unopened vials and keep them away from light. This injection is only for one usage. Discard any leftovers or waste goods.

Safety Advice

warningsAlcohol
Bortether 2 Injection may produce sleepiness when used with alcohol.
warningsPregnancy
Because there is clear evidence of harm to the developing baby, Bortether 2 Injection should not be taken during pregnancy. However, if the benefits outweigh the risks, the doctor would seldom prescribe it in life-threatening situations. Please see your doctor.
warningsBreast feeding 
When breastfeeding, do not take Bortether 2 Injection. According to the information, the drug might be harmful to the newborn.
warningsDriving
Bortether 2 Injection may have negative effects as it may produce fatigue, dizziness, fainting, or impaired vision, which may impair your driving abilities.
warningsKidney
In individuals with severe renal disease, Bortether 2 Injection should be taken with care. Bortether 2 Injection dosage may need to be adjusted. There is little data on the usage of Bortether 2 Injection in these individuals. Please visit your physician. 
warningsLiver
In individuals with liver problems, Bortether 2 Injection should be taken with care. Bortether 2 Injection dosage may need to be adjusted. Please visit your physician.

Quick tips

  • Bortether 2 Injection is administered as an injection into veins or the skin by a healthcare practitioner.
  • Do not miss any doses and finish the course as prescribed by your doctor.
  • To avoid pregnancy while using this drug, use an appropriate method of birth control.
  • During therapy, blood tests may be required to check your blood cells, platelet count, liver function, and kidney function.
  • If you develop coughing, shortness of breath, or foot swelling, contact your doctor right away.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1742-43.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 958.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 153-54.
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link
  5. Bortezomib. Beerse Belgium: Janssen Pharmaceutica NV; [Accessed 26 Mar. 2019] (online) Available from:External Link
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Bortether (Bortezomib) 2mg Injection

Bortether (Bortezomib) 2mg Injection


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Description of product

Bortether | Bortezomib | Velcade | Details, Costing & Pricing

Bortezomib is the active ingredient in the Bortether 2mg injection. It is a chemotherapeutic drug that is used to treat multiple myeloma and mantle cell lymphoma. Multiple myeloma is a malignant development of plasma cells, which are prevalent in bone marrow. Mantle cell lymphoma is a rare malignancy that affects the lymph nodes.

For patients who have not started treatment and are ineligible for blood stem cell transplant, this drug is used in conjunction with other chemotherapy medications such as pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone, or thalidomide.

Uses of Bortether 2 Injection

  • Multiple myeloma.
  • Mantle-cell lymphoma.

Benefits of Bortether 2 Injection

In Multiple myeloma

When you have multiple myeloma, your body destroys bone quicker than it replaces it. This causes bones to become brittle and painful. Bortether 2 Injection may be used in conjunction with other cancer therapies including chemotherapy. It is an important aspect of your therapy and helps patients with multiple myeloma live longer lives. This medication will eliminate the malignant cells and prevent them from growing and spreading to other places of the body. To obtain the best benefit, please follow your doctor's directions. Calcium and Vitamin D3 supplements are also useful and may be administered if you don't have high blood calcium levels.

In Mantle-cell lymphoma

Mantle-cell lymphoma, commonly known as non-lymphoma, Hodgkin's is a malignancy of the white blood cells in our bodies. White blood cells are the cells that aid in the fight against infections. Bortether 2 Injection inhibits cancer development by blocking the action of other chemicals essential for cancer growth and spread. To avoid illness, avoid crowds and wash your hands frequently. Drink plenty of fluids unless your doctor tells you not to.

Side effects of Bortether 2 Injection

Although all medications have side effects, not everyone experiences them. Visit your doctor if they worsen or if you are concerned.

Common side effects

  • Low blood platelets
  • Fatigue
  • Peripheral neuropathy
  • Psychiatric disturbances
  • Nausea
  • Vomiting
  • Loss of appetite
  • Fever
  • Anemia (low number of red blood cells)
  • Diarrhea
  • Decreased appetite
  • Neutrophils (decreased white blood cell count)
  • Constipation

Serious side effects

  • Changes in heartbeat
  • High BP
  • Fainting and tiredness
  • Cough and chest tightness
  • Muscle cramps
  • Confusion, visual disturbances, seizures and headache
  • Breathlessness
  • Swelling of feet

How Bortether 2 Injection works?

Bortether 2 Injection acts by preventing or decreasing protein degradation in cells. As a result, a number of proteins in cancer cells rise, leading to their demise.

How to use Bortether 2 Injection?

This injection should be given by a skilled healthcare provider who is familiar with the administration of cytotoxic drugs.

Interactions with other medications

Consult your physician about any drugs you are now taking or have recently taken.

More information

Refrigerate unopened vials and keep them away from light. This injection is only for one usage. Discard any leftovers or waste goods.

Safety Advice

warningsAlcohol
Bortether 2 Injection may produce sleepiness when used with alcohol.
warningsPregnancy
Because there is clear evidence of harm to the developing baby, Bortether 2 Injection should not be taken during pregnancy. However, if the benefits outweigh the risks, the doctor would seldom prescribe it in life-threatening situations. Please see your doctor.
warningsBreast feeding 
When breastfeeding, do not take Bortether 2 Injection. According to the information, the drug might be harmful to the newborn.
warningsDriving
Bortether 2 Injection may have negative effects as it may produce fatigue, dizziness, fainting, or impaired vision, which may impair your driving abilities.
warningsKidney
In individuals with severe renal disease, Bortether 2 Injection should be taken with care. Bortether 2 Injection dosage may need to be adjusted. There is little data on the usage of Bortether 2 Injection in these individuals. Please visit your physician. 
warningsLiver
In individuals with liver problems, Bortether 2 Injection should be taken with care. Bortether 2 Injection dosage may need to be adjusted. Please visit your physician.

Quick tips

  • Bortether 2 Injection is administered as an injection into veins or the skin by a healthcare practitioner.
  • Do not miss any doses and finish the course as prescribed by your doctor.
  • To avoid pregnancy while using this drug, use an appropriate method of birth control.
  • During therapy, blood tests may be required to check your blood cells, platelet count, liver function, and kidney function.
  • If you develop coughing, shortness of breath, or foot swelling, contact your doctor right away.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1742-43.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 958.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 153-54.
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link
  5. Bortezomib. Beerse Belgium: Janssen Pharmaceutica NV; [Accessed 26 Mar. 2019] (online) Available from:External Link

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