Cytoflu (Flucytosine Tab) is recommended for many diseases such as Adenocarcinoma of the Colon and Rectum, Adenocarcinoma of the Breast, Gastric Adenocarcinoma, Pancreatic Adenocarcinoma, and many more.

Do not take the dose directly, individualize the dose and dosing schedule of Cytoflu (Flucytosine) based on tumor type, the specific regimen administered, disease state, response to treatment, and patient risk factors.

Recommended Dosage for Adenocarcinoma of the Colon and Rectum

• The recommended dose of Cytoflu, administered in an infusional regimen in combination with leucovorin alone, or in combination with leucovorin and oxaliplatin or irinotecan, is 400 mg/m2 by intravenous bolus on Day 1, followed by 2400 mg/m2 to 3000 mg/m2 intravenously as a continuous infusion over 46 hours every two weeks.

• The recommended dose of Cytoflu, if administered in a bolus dosing regimen in combination with leucovorin, is 500 mg/m2 by intravenous bolus on Days 1, 8, 15, 22, 29, and 36 in 8-week cycles.

Recommended Dosage for Adenocarcinoma of the Breast

• The recommended dose of Cytoflu, administered as a component of a cyclophosphamide-based multidrug regimen, is 500 mg/m2 or 600 mg/m2 intravenously on Days 1 and 8 every 28 days for 6 cycles.

Recommended Dosage for Gastric Adenocarcinoma

• The recommended dose of Cytoflu (Flucytosine Tab), administered as a component of a platinum-containing multidrug chemotherapy regimen, is 200 mg/m2 to 1000 mg/m2 intravenously as a continuous infusion over 24 hours. The frequency of dosing in each cycle and the length of each cycle will depend on the dose of Cytoflu and the specific regimen administered.

Recommended Dosage for Pancreatic Adenocarcinoma

• The recommended dose of Cytoflu (Flucytosine Tab), administered as an infusional regimen in combination with leucovorin or as a component of a multidrug chemotherapy regimen that includes leucovorin, is 400 mg/m2 intravenous bolus on Day 1, followed by 2400 mg/m2 intravenously as a continuous infusion over 46 hours every two weeks.

Dose Modifications

Withhold Cytoflu for any of the following:

• Development of angina, myocardial infarction/ischemia, arrhythmia, or heart failure in patients with no history of coronary artery disease or myocardial dysfunction
• Hyperammonemic encephalopathy
• Acute cerebellar syndrome, confusion, disorientation, ataxia, or visual disturbances
• Grade 3 or 4 diarrhea
• Grade 2 or 3 palmar-plantar erythrodysesthesia (hand-foot syndrome)
• Grade 3 or 4 mucositis
• Grade 4 myelosuppression

Upon resolution or improvement to Grade 1 diarrhea, mucositis, myelosuppression, or palmar-plantar erythrodysesthesia, resume Cytoflu administration at a reduced dose.

There is no recommended dose for resumption of Cytoflu administration following the development of any of the following adverse reactions:

• Cardiac toxicity
• Hyperammonemic encephalopathy
• Acute cerebellar syndrome, confusion, disorientation, ataxia, or visual disturbances.

CONCLUSION

Some people may experience some side effects like nausea, vomiting, diarrhea, and skin rash. Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

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